TY  - JOUR
PY  - 2023//
TI  - The Australian Traumatic Brain Injury Initiative: systematic review of predictive value of biological markers for people with moderate-severe traumatic brain injury
JO  - Journal of neurotrauma
A1  - Bagg, Matthew
A1  - Hellewell, Sarah Claire
A1  - Keeves, Jemma
A1  - Antonic-Baker, Ana
A1  - McKimmie, Ancelin
A1  - Hicks, Amelia
A1  - Gadowski, Adelle
A1  - Newcombe, Virginia
A1  - Barlow, Karen Maria
A1  - Balogh, Zsolt
A1  - Ross, Jason
A1  - Law, Meng
A1  - Caeyenberghs, Karen
A1  - Parizel, Paul
A1  - Thorne, Jacinta
A1  - Papini, Melissa
A1  - Gill, Geena
A1  - Jefferson, Amanada
A1  - Ponsford, Jennie
A1  - Lannin, Natasha A.
A1  - O'Brien, Terence J.
A1  - Cameron, Peter
A1  - Cooper, D. James
A1  - Rushworth, Nick
A1  - Gabbe, Belinda
A1  - Fitzgerald, Melinda
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: The Australian Traumatic Brain Injury Initiative (AUS-TBI) aims to co-design a data resource to predict outcomes for people with moderate-severe TBI across Australia. Fundamental to this resource is the data dictionary; an ontology of data items. Here, we report the systematic review and consensus process for inclusion of biological markers in the data dictionary. <br><br>METHODS: Standardised database searches were implemented from inception through April 2022. English-language studies evaluating association between a fluid, tissue or imaging marker and any clinical outcome in at least ten patients with moderate-severe TBI were included. Records were screened using a prioritisation algorithm and saturation threshold in Research Screener. Full-length records were then screened in Covidence. A predefined algorithm was used to assign a judgement of predictive value to each observed association, and high-value predictors were discussed in a consensus process. <br><br>FINDINGS: Searches retrieved 106,593 records. 1,417 full-length records were screened, resulting in 546 included records. 239 individual markers were extracted, evaluated against 101 distinct outcomes. 44 markers were judged to be high-value predictors of 15 outcomes. Fluid markers retained following the consensus process included neuron specific enolase, ubiquitin C-terminal Hydrolase L1 and glial fibrillary acidic protein. Imaging markers included CT scores (e.g., Marshall), pathological observations (e.g., haemorrhage, midline shift), and MRI (e.g., diffuse axonal injury). The clinical context and time of sampling of potential predictive indicators are important considerations for utility. <br><br>CONCLUSIONS: This systematic review and consensus process has identified fluid and imaging biomarkers with high predictive value of clinical and long-term outcomes following moderate-severe TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2023.0464
ID  - ref1
ER  -