TY  - JOUR
PY  - 2024//
TI  - Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study
JO  - Scientific reports
A1  - Nguyen, Hoa T.
A1  - Nguyen, Bao T.
A1  - Thai, Thi H. Nhung
A1  - Tran, An V.
A1  - Nguyen, Tan T.
A1  - Vo, Tam
A1  - Mai, Linh D.
A1  - Tran, Thach S.
A1  - Nguyen, Tuan V.
A1  - Ho-Pham, Lan T.
SP  - e32
EP  - e32
VL  - 14
IS  - 1
N2  - The epidemiology of vertebral fractures (VF) in underrepresented populations is not well-documented. This cohort study was part of a longitudinal osteoporosis research project with the aim of determining the prevalence, incidence, and risk factors for VF. 401 individuals (155 men) aged 50 years and older without a clinical diagnosis of VF were took radiographs at baseline and 2 years later. VF were ascertained using the Genant's semi-quantitative method. Bone mineral density (BMD) of femoral neck and lumbar spine were measured by dual-energy X-ray absorptiometry (Hologic Inc). The association between VF and risk factors was analyzed by the multiple logistic regression. The 95% confidence interval for prevalence and incidence was estimated by exact Poisson test. At baseline, the prevalence of VF was 12.2% (n = 49, 95% CI 9.0-16.2%) and increased with advancing age with one-fifth of those aged 70 and older having a VF. During the follow-up period, we observed 6 new VF, making the incidence of 6.6/1000 person-years (n = 6, 95% CI 2.4-14.3). The risk of prevalent VF was associated with male gender (OR: 2.67; 95% CI 1.28-5.87) and T-score at the femoral neck (OR per one SD decrease: 1.1; 1.03-1.17). These data indicate that VF is common among adults, and that lower femoral neck BMD was a risk factor for VF.<p />  <p>Language: en</p>
LA  - en
SN  - 2045-2322
UR  - http://dx.doi.org/10.1038/s41598-023-50145-w
ID  - ref1
ER  -