TY  - JOUR
PY  - 2024//
TI  - The Australian Traumatic Brain Injury Initiative: systematic review of the effect of acute interventions on outcome for people with moderate-severe traumatic brain injury
JO  - Journal of neurotrauma
A1  - Keeves, Jemma
A1  - Gadowski, Adelle
A1  - McKimmie, Ancelin
A1  - Bagg, Matthew
A1  - Antonic-Baker, Ana
A1  - Clarke, Nyssa
A1  - Reeder, Sandra
A1  - Hicks, Amelia
A1  - Brown, Alastair
A1  - McNamara, Robert
A1  - Roman, Cristina
A1  - Jeffcote, Toby
A1  - Romero, Lorena
A1  - Hill, Regina
A1  - Ponsford, Jennie
A1  - Lannin, Natasha A.
A1  - O'Brien, Terence J.
A1  - Cameron, Peter
A1  - Rushworth, Nick
A1  - Fitzgerald, Melinda
A1  - Gabbe, Belinda
A1  - Cooper, D. James
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: The Australian Traumatic Brain Injury Initiative (AUS-TBI) is developing a data resource to enable improved outcome prediction for people with moderate-severe TBI (msTBI) across Australia. Fundamental to this resource is the collaboratively designed data dictionary. This systematic review and consultation aimed to identify acute interventions with potential to modify clinical outcomes for people after msTBI, inclusion in a data dictionary. <br><br>METHODS: Standardised searches were implemented across bibliographic databases from inception through April 2022. English-language reports of randomised controlled trials (RCTs) evaluating any association between any acute intervention and clinical outcome, in at least 100 patients with msTBI were included. A predefined algorithm was used to assign a value to each observed association. Consultation with AUS-TBI clinicians and researchers formed the consensus process for interventions to be included in a single data dictionary. <br><br>FINDINGS: Searches retrieved 14,455 records, of which 124 full-length RCTs were screened, with 35 studies included. These studies evaluated 26 unique acute interventions across 21 unique clinical outcomes. Only four interventions were considered to have medium modifying value for any outcome from the review, with an additional eight interventions agreed upon through the consensus process. The interventions with medium value were tranexamic acid and phenytoin, which had a positive effect on an outcome; and decompressive craniectomy surgery and hypothermia, which negatively affected outcomes. <br><br>CONCLUSIONS: From the systematic review and consensus process, 12 interventions were identified as potential modifiers to be included in the AUS-TBI national data resource.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2023.0465
ID  - ref1
ER  -