TY  - JOUR
PY  - 2024//
TI  - Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy
JO  - Molecular psychiatry
A1  - Tully, John
A1  - Pereira, Andreia C.
A1  - Sethi, Arjun
A1  - Griem, Julia
A1  - Cross, Ben
A1  - Williams, Steve Cr
A1  - Blair, Robert James
A1  - Murphy, Declan
A1  - Blackwood, Nigel
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Men with antisocial personality disorder (ASPD) with or without psychopathy (+/-P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition. Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies. However, to date, no study has directly examined the potential neurochemical underpinnings of such abnormalities. We therefore investigated striatal glutamate: GABA ratio using Magnetic Resonance Spectroscopy in 30 violent offenders (16 ASPD-P, 14 ASPD + P) and 21 healthy non-offenders. Men with ASPD +/- P had a significant reduction in striatal glutamate : GABA ratio compared to non-offenders. We report, for the first time, striatal Glutamate/GABA dysregulation in ASPD +/- P, and discuss how this may be related to core behavioral abnormalities in the disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 1359-4184
UR  - http://dx.doi.org/10.1038/s41380-024-02437-4
ID  - ref1
ER  -