TY  - JOUR
PY  - 2023//
TI  - Brain dynamics in triple-network interactions and its relation to multiple cognitive impairments in mild traumatic brain injury
JO  - Cerebral cortex
A1  - Li, Xuan
A1  - Jia, Xiaoyan
A1  - Liu, Yuling
A1  - Bai, Guanghui
A1  - Pan, Yizhen
A1  - Ji, Qiuyu
A1  - Mo, Zhaoyi
A1  - Zhao, Wenpu
A1  - Wei, Yixin
A1  - Wang, Shan
A1  - Yin, Bo
A1  - Zhang, Jie
A1  - Bai, Lijun
SP  - 6620
EP  - 6632
VL  - 33
IS  - 11
N2  - Traumatic brain injury (TBI) disrupt the coordinated activity of triple-network and produce impairments across several cognitive domains. The triple-network model posits a key role of the salience network (SN) that regulates interactions with the central executive network (CEN) and default mode network (DMN). However, the aberrant dynamic interactions among triple-network and associations with neurobehavioral symptoms in mild TBI was still unclear. In present study, we used brain network interaction index (NII) and dynamic functional connectivity to examine the time-varying cross-network interactions among the triple-network in 109 acute patients, 41 chronic patients, and 65 healthy controls. Dynamic cross-network interactions were significantly increased and more variable in mild TBI compared to controls. Crucially, mild TBI exhibited an increased NII as enhanced integrations between the SN and CEN while reduced coupling of the SN with DMN. The increased NII also implied much severer and multiple domains of cognitive impairments at both acute and chronic mild TBI. Abnormities in time-varying engagement of triple-network is a clinically relevant neurobiological signature of psychopathology in mild TBI. The findings provided align with and advance an emerging perspective on the importance of aberrant brain dynamics associated with highly disparate cognitive and behavioral outcomes in trauma.<p />  <p>Language: en</p>
LA  - en
SN  - 1047-3211
UR  - http://dx.doi.org/10.1093/cercor/bhac529
ID  - ref1
ER  -