TY  - JOUR
PY  - 2007//
TI  - Deliberate self-poisoning with Tiagabine: An unusual toxidrome
JO  - Emergency medicine Australasia
A1  - Forbes, Richard A.
A1  - Kalra, Harish
A1  - Hackett, L. Peter
A1  - Daly, Frank F.
SP  - 556
EP  - 558
VL  - 19
IS  - 6
N2  - Tiagabine is an anticonvulsant acting by selective inhibition of neuronal and glial gamma-aminobutyric acid uptake, resulting in increased gamma-aminobutyric acid-mediated inhibition in the brain. Few reports in the literature describe the clinical course of severe tiagabine intoxication. A 44-year-old woman presented after deliberate self-poisoning with 100 tiagabine 15 mg tablets (1500 mg; 25 mg/kg). Serum tiagabine level was 4600 microg/L (1725 mmol/L) at presentation, 20 times levels associated with therapeutic dosing. Intoxication was manifested by profuse vomiting, coma, myoclonus, generalized rigidity, bradycardia, hypertension, hypersalivation and generalized piloerection within 2 h of ingestion. The patient was intubated and management was supportive. Coma lasted until 10 h post-ingestion, but recovery was complicated by severe agitated delirium lasting 12 h. The patient recovered fully within 26 h of ingestion. Tiagabine deliberate self-poisoning was associated with the rapid onset of coma and an unusual toxidrome. Recovery, although complicated by agitated delirium, was complete within 26 h.<p />  <p>Language: en</p>
LA  - en
SN  - 1742-6731
UR  - http://dx.doi.org/10.1111/j.1742-6723.2007.00973.x
ID  - ref1
ER  -