TY  - JOUR
PY  - 2024//
TI  - Mean corpuscular volume as a prognostic factor for 30-day mortality in major trauma patients: a retrospective cohort study
JO  - Scientific reports
A1  - Choi, Hanlim
A1  - Lee, Jin Young
A1  - Sul, Younghoon
A1  - Kim, Se Heon
A1  - Ye, Jin Bong
A1  - Lee, Jin Suk
A1  - Yoon, Soo Young
A1  - Seok, Junepill
A1  - Choi, Jung Hee
SP  - e3951
EP  - e3951
VL  - 14
IS  - 1
N2  - We investigated the clinical implications of the mean corpuscular volume (MCV) in patients with major trauma. This single-center retrospective review included 2021 trauma patients admitted to the intensive care unit between January 2016 and June 2020. We included 1218 patients aged [Formula: see text] 18 years with an injury severity score [Formula: see text] 16 in the final analysis. The clinical and laboratory variables were compared between macrocytosis (defined as MCV [Formula: see text] 100 fL) and non-macrocytosis groups. Cox regression analysis was performed to calculate the hazard ratios (HRs) of variables for 30-day mortality, with adjustment for other potential confounding factors. The initial mean value of MCV was 102.7 fL in the macrocytosis group (n = 199) and 93.7 fL in the non-macrocytosis group (n = 1019). The macrocytosis group showed a significantly higher proportion of initial hypotension, transfusion within 4 and 24 h, and 30-day mortality than the non-macrocytosis group. Age ([Formula: see text] 65 years), hypotension (systolic blood pressure [Formula: see text] 90 mmHg), transfusion (within 4 h), anemia (Hb < 12 g/day in women, < 13 g/day in men), and macrocytosis were significantly associated with 30-day mortality (adjusted HR = 1.4; 95% confidence interval 1.01-1.94; p = 0.046) in major trauma patients. Thus, initial macrocytosis independently predicted 30-day mortality in patients with major trauma at a Level I trauma center.<p />  <p>Language: en</p>
LA  - en
SN  - 2045-2322
UR  - http://dx.doi.org/10.1038/s41598-024-54057-1
ID  - ref1
ER  -