TY - JOUR
PY - 2024//
TI - Interaction between PTSD-PRS and trauma affects PTSD likelihood in women victims of sexual assault
JO - Revista brasileira de psiquiatria
A1 - Bugiga, Amanda Victória Gomes
A1 - Carvalho, Carolina Muniz
A1 - Oliveira, Adrielle Martins
A1 - Coimbra, Bruno Messina
A1 - Chehimi, Samar Nasser
A1 - Zanardo, Evelin Aline
A1 - Kulikowski, Leslie Domenici
A1 - Mello, Andrea Feijó
A1 - Ota, Vanessa Kiyomi
A1 - Mello, Marcelo Feijo
A1 - Belangero, Sintia Iole
SP - ePub
EP - ePub
VL - ePub
IS - ePub
N2 - OBJECTIVE: Post-traumatic stress disorder (PTSD) is triggered by traumatic events, but genetic vulnerability and a history of childhood trauma are additional factors that may increase the risk of PTSD. Thus, our study focused on exploring the interaction between genetic susceptibility, as assessed by polygenic risk score (PRS), and traumatic events.
METHODS: We evaluated 68 women with PTSD who had been sexually assaulted and 63 healthy controls without a history of sexual assault. DNA was genotyped using the Infinium Global Screening Array (Illumina), and PRS analysis was performed using PRSice. Furthermore, logistic regression models were employed to examine the interaction between childhood trauma, traumatic life events, and PTSD-PRS and how they contribute to the risk of developing PTSD.
RESULTS: We found a significant association between PRS, childhood trauma (p = 0.03; OR = 1.241), and PTSD. Additionally, an interaction was observed between PRS, traumatic life events, and childhood trauma, particularly relating to physical and emotional neglect (p = 0.028; OR = 1.010). When examining neglect separately, we found a modest association between emotional neglect and PTSD (p = 0.014; OR = 1.086).
CONCLUSIONS: Our findings highlight the importance of considering genetic vulnerability and traumatic experiences in understanding the etiology of PTSD. Language: en
LA - en
SN - 1516-4446
UR - http://dx.doi.org/10.47626/1516-4446-2023-3335
ID - ref1
ER -