TY  - JOUR
PY  - 2024//
TI  - Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J-SUPPORT 2001 Study)
JO  - Psychiatry and the Clinical Neurosciences
A1  - Akechi, Tatsuo
A1  - Furukawa, Toshiaki A.
A1  - Noma, Hisashi
A1  - Iwata, Hiroji
A1  - Toyama, Tatsuya
A1  - Higaki, Kenji
A1  - Matsuoka, Hiromichi
A1  - Zenda, Sadamoto
A1  - Iwatani, Tsuguo
A1  - Akahane, Kazuhisa
A1  - Inoue, Akira
A1  - Sagara, Yasuaki
A1  - Uchida, Megumi
A1  - Imai, Fuminobu
A1  - Momino, Kanae
A1  - Imaizumi, Gen
A1  - Yamaguchi, Takuhiro
A1  - Mashiko, Tomoe
A1  - Miyaji, Tempei
A1  - Horikoshi, Masaru
A1  - Sakurai, Naomi
A1  - Onishi, Tatsuya
A1  - Kanemitsu, Yukihide
A1  - Murata, Takeshi
A1  - Wanifuchi-Endo, Yumi
A1  - Kuroda, Hiroaki
A1  - Nishikawa, Ryutaro
A1  - Miyashita, Minoru
A1  - Abe, Masakazu
A1  - Uchitomi, Yosuke
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - AIM: Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom. <br><br>METHODS: This was a decentralized, parallel-group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive-behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem-solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire-9 (PHQ-9) total score between baseline and week 8. Secondary outcomes included anxiety. <br><br>RESULTS: In total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ-9 total score was significantly reduced from baseline for all participants by -1.41 points (95% confidence interval [CI] -1.89, -0.92), but between-group differences in change scores were not significant (BA: -0.04, 95% CI -0.75, 0.67; AT: -0.16, 95% CI -0.87, 0.55; PS: -0.19, 95% CI -0.90, 0.52). <br><br>CONCLUSION: As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence-based recommendations regarding the use of specific smartphone psychotherapy.<p />  <p>Language: en</p>
LA  - en
SN  - 1323-1316
UR  - http://dx.doi.org/10.1111/pcn.13657
ID  - ref1
ER  -