TY  - JOUR
PY  - 2024//
TI  - Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ADORA2A, B4GALT2 and MMP14
JO  - Epigenomics
A1  - Arčan, Iris Šalamon
A1  - Kouter, Katarina
A1  - Zupanc, Tomaz
A1  - Paska, Alja Videtič
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Materials & methods: Level of H3K14ac was studied with chromatin immunoprecipitation followed by high-throughput DNA sequencing. Genes were further validated with RT-qPCR; using hippocampal tissue. <br><br>RESULTS: We showed lowered H3K14ac levels in individuals who died by suicide. The genes ADORA2A, B4GALT2 and MMP14 showed differential expression in individuals who died by suicide. Identified genetic and protein interactions among genes show interactions with suicide-related genes. <br><br>CONCLUSION: Further investigations of histone modifications in association with DNA methylation and miRNA are needed to expand our knowledge of the genes that could significantly contribute to suicide.<p />  <p>Language: en</p>
LA  - en
SN  - 1750-1911
UR  - http://dx.doi.org/10.2217/epi-2023-0351
ID  - ref1
ER  -