TY  - JOUR
PY  - 2024//
TI  - Acute thyroid hormone exposure in children: a national retrospective study using health data routinely collected by the French poison control centers
JO  - Indian journal of pediatrics
A1  - Paradis, Camille
A1  - Courtois, Arnaud
A1  - Vaucel, Jules-Antoine
A1  - Blanc-Brisset, Ingrid
A1  - Record, Cécile
A1  - Grenet, Guillaume
A1  - Gomes, Elisabete
A1  - Nardon, Audrey
A1  - Louviaux, Natacha
A1  - Labadie, Magali
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - To the Editor: The published case reports of L-thyroxine poisoning in children are scarce and the published case series included small numbers of patients, making it difficult to draw clear conclusions about L-thyroxine's exposure epidemiology and severity [1,2,3]. Therefore, in this historical cohort, based on French Poison Control Center records, we describe the epidemiology, the clinical symptoms and outcomes related to thyroid hormone exposure in patients until 12-y-old from 1st January 2018 to 31st December 2020.     Among the 1,248 cases of exposure, preschool children (2-5 y) accounted for 935 cases (75%). Of these cases, boys were more involved than girls (Supplementary Table S1). The exposures were unintentional, intentional, or unknown in 1,225 (98.2%), 14 (1%), and 9 (0.8%) cases, respectively. Among intentional cases, 5 (0.4%) were suicide attempts involving children aged 8-12 y. In 97.5% of the cases, the drug belonged to a relative of the child. Overall, 10 children (0.8%) were symptomatic, and the severity was classified as minor (poisoning severity score = 1 [4], Supplementary Table S1). The symptoms reported were agitation (four children), diarrhea (two children), tachycardia (two children), vomiting (one child), and tremor (one child). The assumed ingested dose was 20.6 ± 33.8 (0.36-500) µg/kg for asymptomatic patients and 33.3 ± 27.6 (6.67-71.4) µg/kg for symptomatic patients. All of the symptomatic children fully recovered. Plasma thyroid hormone levels were measured only in 14 asymptomatic children and 2 symptomatic children. Of the two symptomatic patients, an increase in thyroid hormones plasma levels was seen in one child 7 d after ingestion. Among the 14 asymptomatic patients, this increase was objective in 5 children between 24 h and 7 d after ingestion. ...<p />  <p>Language: en</p>
LA  - en
SN  - 0019-5456
UR  - http://dx.doi.org/10.1007/s12098-024-05114-0
ID  - ref1
ER  -