TY  - JOUR
PY  - 2024//
TI  - Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
JO  - Nature
A1  - Jiang-Xie, Li-Feng
A1  - Drieu, Antoine
A1  - Bhasiin, Kesshni
A1  - Quintero, Daniel
A1  - Smirnov, Igor
A1  - Kipnis, Jonathan
SP  - 157
EP  - 164
VL  - 627
IS  - 8002
N2  - The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of macroscopic brain waves.<p />  <p>Language: en</p>
LA  - en
SN  - 0028-0836
UR  - http://dx.doi.org/10.1038/s41586-024-07108-6
ID  - ref1
ER  -