TY  - JOUR
PY  - 2024//
TI  - Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: a systematic review and meta-analysis
JO  - Biomolecules and biomedicine
A1  - Tao, Xiaoyang
A1  - Yang, Wupeng
A1  - Zhang, Qinxin
A1  - Wang, Yongjiang
A1  - Gao, Feng
A1  - Wang, Yuehan
A1  - Zhang, Tingxin
A1  - Liu, Hao
A1  - Chen, Jindong
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Vitamin D is commonly used to prevent and treat osteoporosis, with studies indicating its potential to reduce fractures, falls, and mortality. However, meta-analyses present inconsistent findings regarding its efficacy, particularly reflecting significant variability in data and outcomes related to various dosing regimens. In this meta-analysis, we assessed the impact of high-dose intermittent oral administration of vitamin D3 on serum 25(OH)D levels, fractures, falls, and mortality among elderly individuals. We included 14 randomized controlled trials (RCTs) and employed Review Manager 5.4 for statistical analysis. Our findings indicate that intermittent monthly administration of vitamin D3 (over 800 IU per day) significantly raised serum 25(OH)D levels at all timepoints after six months, maintaining levels above 75 nmol/L throughout the year. This regimen showed no increase in all-cause mortality, with a risk ratio (95% CI) of 0.95 (0.87-1.04). Likewise, it did not significantly reduce the risks of falls and fractures, with risk ratios of 1.02 (0.98-1.05) and 0.95 (0.87-1.04) respectively. Although one-year intermittent administration significantly increased the concentration of 25(OH)D in serum, further research is needed to determine if this method would increase the incidence of falls. Therefore, it is not recommended at this stage due to the lack of demonstrated safety in additional relevant RCTs. This study had been registered on PROSPERO (CRD42022363229).<p />  <p>Language: en</p>
LA  - en
SN  - 2831-0896
UR  - http://dx.doi.org/10.17305/bb.2024.10449
ID  - ref1
ER  -