TY  - JOUR
PY  - 2024//
TI  - Transforming research to improve therapies for trauma in the twenty-first century: an alternative perspective
JO  - Critical care : the Official Journal of the Critical Care Forum
A1  - Dobson, Geoffrey P.
A1  - Morris, Jodie L.
A1  - Letson, Hayley L.
SP  - e135
EP  - e135
VL  - 28
IS  - 1
N2  - We read with interest the perspective of Juffermans and colleagues on transforming research to improve therapies for trauma care in the twenty-first century [1]. We would like to offer a different perspective. We think a more interesting approach is to ask how historians of science 50 or 100 years from now might view our progress in the early twenty-first century? Instead of looking into the future from where we stand today, we move the needle into the future and reflect backwards. We agree with Juffermans and colleagues that specific treatments for bleeding are largely lacking [1], however, they fail to delve deeper. Why are there so few safe and effective drugs to treat hemorrhage, traumatic brain injury or burn trauma? Why have there been so few breakthroughs? We argue the lack of drug therapies is a consequence of the treat-as-you-go symptoms-based approach, rather than a more integrated systems-based approach [2, 3]. The current practice of identifying and treating one defect at a time, and so on down the line, often leads to what US trauma surgeon William C. Shoemaker deemed: "an uncoordinated and sometimes contradictory therapeutic outcome" [4]. In the twenty-first century, a new revolution is required to better understand how the body responds to trauma, identify new markers to detect its progression and discover new system-acting drugs to treat it. ...<p />  <p>Language: en</p>
LA  - en
SN  - 1364-8535
UR  - http://dx.doi.org/10.1186/s13054-024-04913-3
ID  - ref1
ER  -