TY  - JOUR
PY  - 2024//
TI  - Sex-differential cognitive performance on MCCB of youth with BD-II depression
JO  - BMC psychiatry
A1  - Huang, Dong
A1  - Lai, Shunkai
A1  - Zhong, Shuming
A1  - Zhang, Yiliang
A1  - He, Jiali
A1  - Yan, Shuya
A1  - Huang, Xiaosi
A1  - Lu, Xiaodan
A1  - Duan, Manying
A1  - Song, Kailin
A1  - Ye, Kaiwei
A1  - Chen, Yandi
A1  - Ye, Suiyi
A1  - Lai, Jiankang
A1  - Zhong, Qilin
A1  - Song, Xiaodong
A1  - Jia, Yanbin
SP  - e345
EP  - e345
VL  - 24
IS  - 1
N2  - BACKGROUND: Recent evidences have shown sex-differential cognitive deficits in bipolar disorder (BD) and differences in cognitions across BD subtypes. However, the sex-specific effect on cognitive impairment in BD subtype II (BD-II) remains obscure. The aim of the current study was to examine whether cognitive deficits differ by gender in youth with BD-II depression. <br><br>METHOD: This cross-sectional study recruited 125 unmedicated youths with BD-II depression and 140 age-, sex-, and education-matched healthy controls (HCs). The Chinese version of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was used to assess cognitive functions. Mood state was assessed using the 24-item Hamilton Depression Rating Scale (24-HDRS) and the Young Mania Rating Scale (YMRS). Multivariate analysis of covariance (MANCOVA) was conducted. <br><br>RESULT: ​Compared with HCs, patients with BD-II depression had lower scores on MCCB composite and its seven cognitive domains (all p < 0.001). After controlling for age and education, MANCOVA revealed significant gender-by-group interaction on attention/vigilance (F = 6.224, df = 1, p = 0.013), verbal learning (F = 9.847, df = 1, p = 0.002), visual learning (F = 4.242, df = 1, p = 0.040), and composite (F = 8.819, df = 1, p = 0.003). Post hoc analyses suggested that males performed worse in the above-mentioned MCCB tests than females in BD-II depression. <br><br>CONCLUSION: Our study demonstrated generalized cognitive deficits in unmedicated youths with BD-II depression. Male patients performed more serious cognitive impairment on attention/vigilance, verbal learning, and visual learning compared to female patients.<p />  <p>Language: en</p>
LA  - en
SN  - 1471-244X
UR  - http://dx.doi.org/10.1186/s12888-024-05701-7
ID  - ref1
ER  -