TY  - JOUR
PY  - 2000//
TI  - Massive noninflammatory periportal liver necrosis following concentrated acetic acid ingestion
JO  - Archives of pathology and laboratory medicine
A1  - Kamijo, Y.
A1  - Soma, K.
A1  - Iwabuchi, K.
A1  - Ohwada, T.
SP  - 127
EP  - 129
VL  - 124
IS  - 1
N2  - In a fatal occurrence of massive liver necrosis following ingestion of concentrated (90%) acetic acid, the patient showed evidence of hemolysis, disseminated intravascular coagulation, and liver dysfunction at only 45 minutes after exposure. With refractory to vigorous supportive care, the patient s condition deteriorated until death occurred 39 hours after ingestion, despite some improvement of coagulopathy. Autopsy revealed corrosive injuries in the upper gastrointestinal tract and massive hepatic necrosis in a periportal distribution without significant inflammation. A direct effect of the noxious agent on hepatocytes involving the portal circulation is suggested.<p />  <p>Language: en</p>
LA  - en
SN  - 0003-9985
UR  - http://dx.doi.org/10.5858/2000-124-0127-MNPLNF
ID  - ref1
ER  -