TY  - JOUR
PY  - 1999//
TI  - Chlorpropamide toxicity with survival despite 27-day hypoglycemia
JO  - Journal of toxicology - clinical toxicology
A1  - Ciechanowski, K.
A1  - Borowiak, K. S.
A1  - Potocka, B. A.
A1  - Nowacka, M.
A1  - Dutkiewicz, G.
SP  - 869
EP  - 871
VL  - 37
IS  - 7
N2  - In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 4:1 has made this antidiabetic agent obsolete.<p />  <p>Language: en</p>
LA  - en
SN  - 0731-3810
UR  - http://dx.doi.org/10.1081/clt-100102468
ID  - ref1
ER  -