TY  - JOUR
PY  - 2017//
TI  - Clonazepam improves dopamine supersensitivity in a schizophrenia patient: a case report
JO  - Therapeutic advances in psychopharmacology
A1  - Fukai, M.
A1  - Hirosawa, T.
A1  - Takahashi, T.
A1  - Kaneda, R.
A1  - Kikuchi, M.
A1  - Minabe, Y.
SP  - 113
EP  - 117
VL  - 7
IS  - 3
N2  - Dopamine supersensitivity is an important consideration for assessing treatment-resistant schizophrenia. The emergence of dopamine supersensitivity might be related to upregulation of dopamine D2 receptor, which engenders tolerance to antipsychotics, rebound psychosis, and tardive dyskinesia (TD). A 24-year-old man with a history of treatment-resistant schizophrenia was hospitalized for treatment of bone fracture sustained during a suicide attempt. After the operation, his clinical symptoms implied malignant catatonia. The patient discontinued antipsychotics without rebound psychosis under clonazepam treatment. His psychotic symptoms were controlled further with 24 mg/day aripiprazole without relapse or worsening. Clonazepam might be an effective option for the management of dopamine supersensitivity psychosis (DSP). © 2016, © The Author(s), 2016.<p /> <p>Language: en</p>
LA  - en
SN  - 2045-1253
UR  - http://dx.doi.org/10.1177/2045125316681750
ID  - ref1
ER  -