TY  - JOUR
PY  - 2024//
TI  - Exaggerated sensitivity to threat and reduced medial prefrontal engagement during threat generalization in reactive aggressive adolescents
JO  - NeuroImage
A1  - Wang, Yizhen
A1  - Becker, Benjamin
A1  - Wang, Jinxia
A1  - Wang, Yuanyuan
A1  - Zhang, Liangyou
A1  - Mei, Ying
A1  - Li, Hong
A1  - Lei, Yi
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Aggressive adolescents tend to exhibit abnormal fear acquisition and extinction, and reactive aggressive adolescents are often more anxious. However, the relationship between fear generalization and reactive aggression (RA) remains unknown. According to Reactive-Proactive Aggression Questionnaire (RPQ) scores, 61 adolescents were divided into two groups, namely, a high RA group (N=30) and a low aggression (LA) group (N=31). All participants underwent three consecutive phases of the Pavlovian conditioning paradigm (i.e., habituation, acquisition, and generalization), and neural activation of the medial prefrontal cortex (mPFC) was assessed by functional near-infrared spectroscopy (fNIRS). The stimuli were ten circles with varying sizes, including two conditioned stimuli (CSs) and generalization stimuli (GSs). A scream at 85 decibels served as the auditory unconditioned stimulus (US). The US expectancy ratings of both CSs and GSs were higher in the RA group than in the LA group. The fNIRS results showed that GSs evoked lower mPFC activation in the RA group compared to the LA group during fear generalization. These findings suggest that abnormalities in fear acquisition and generalization are prototypical dysregulations in adolescents with RA. They provide neurocognitive evidence for dysregulated fear learning in the mechanisms underlying adolescents with RA, highlighting the need to develop emotional regulation interventions for these individuals.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8119
UR  - http://dx.doi.org/10.1016/j.neuroimage.2024.120645
ID  - ref1
ER  -