TY  - JOUR
PY  - 2024//
TI  - Association of depressive symptoms with incident fractures: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT)
JO  - Osteoporosis international
A1  - Funakoshi, Yayoi
A1  - Maruyama, Koutatsu
A1  - Kato, Tadahiro
A1  - Saito, Isao
A1  - Takanashi, Nobuyuki
A1  - Tanno, Kozo
A1  - Yamagishi, Kazumasa
A1  - Muraki, Isao
A1  - Yasuda, Nobufumi
A1  - Arima, Kazuhiko
A1  - Nakashima, Hiroki
A1  - Yamaji, Taiki
A1  - Iwasaki, Motoki
A1  - Inoue, Manami
A1  - Tsugane, Shoichiro
A1  - Sawada, Norie
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - This 5-year longitudinal study investigated the relationship between depressive symptoms and fracture risk in a large Japanese cohort. Depressive symptoms were a significant risk factor for hip fractures in women. <br><br>PURPOSE: A relationship between depressive symptoms and fractures has not been clearly demonstrated. We aimed to investigate the relationship between depressive symptoms and 5-year fracture risk in the Japan Public Health Center-based Prospective Study for the Next Generation. <br><br>METHODS: From 2011 to 2016, 114,092 participants were enrolled, and a follow-up survey was conducted 5 years later. We analyzed 30,552 men and 38,063 women aged 40-74 years who had no past fractures at baseline. Presence of depressive symptoms was defined as a modified 11-item Center for Epidemiological Studies Depression Scale score of 8 or higher, a history of depression, or use of antidepressants. Subjects were asked to report vertebral, upper limb, and/or hip fractures, except for traffic or work accidents, that occurred during the follow-up period. The adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for fracture were analyzed via logistic regression analysis to evaluate the relationship between depressive symptoms and fracture. <br><br>RESULTS: Women with depressive symptoms demonstrated a high AOR for hip fractures (AOR: 2.78, 95% CI: 1.30 - 5.92); this result was consistent in post menopause women. In men, this association was not found for any age group or any type of fracture. <br><br>CONCLUSIONS: Depressive symptoms in women may increase the risk of hip fractures. Further studies are required to explore this relationship in more detail.<p />  <p>Language: en</p>
LA  - en
SN  - 0937-941X
UR  - http://dx.doi.org/10.1007/s00198-024-07106-4
ID  - ref1
ER  -