TY  - JOUR
PY  - 1998//
TI  - Synthesis of the suicide substrate D-propargylglycine stereospecifically labelled with deuterium and investigation of its oxidation by D-amino acid oxidase
JO  - Journal of the Chemical Society - Perkin Transactions 1
A1  - Church, N.J.
A1  - Young, D.W.
SP  - 1475
EP  - 1482
VL  - 
IS  - 9
N2  - Stereospecifically deuteriated samples of D-propargylglycine 1 have been prepared by reaction of the labelled Pmc-protected aziridine free acids 22 with a lithium acetylide followed by deprotection. These samples have been used to show that D-amino acid oxidase, in converting D-propargylglycine to the lactone 5, deprotonates C-3 in a non-stereospecific manner. This strongly supports the idea that non-enzymic deprotonation is a key step in the formation of this compound.<p /> <p>Language: en</p>
LA  - en
SN  - 0300-922X
UR  - http://dx.doi.org/10.1039/a800579f
ID  - ref1
ER  -