TY  - JOUR
PY  - 2000//
TI  - Post-mortem studies of brain phosphatidylinositol hydrolysis in depression and the effect of antidepressant treatment
JO  - International journal of neuropsychopharmacology
A1  - Coull, M.A.
A1  - Lowther, S.
A1  - Katona, C.L.E.
A1  - Horton, R.W.
SP  - 109
EP  - 115
VL  - 3
IS  - 2
N2  - Basal, neurotransmitter and G protein-mediated [3H]PI hydrolysis was measured in the frontal cortex, temporal cortex, hippocampus and thalamus from suicides, with a firm retrospective diagnosis of depression, and individually matched controls. Suicides were divided into those who had been free of antidepressant drugs for at least 3 months and those in whom prescription of antidepressants was clearly documented. There were no significant differences in basal, GTPγS-, 5-HT- or ACPD-stimulated [3H]PI hydrolysis in either antidepressant-free or antidepressant-treated suicides and their respective controls in the four brain regions studied. This was also the case when suicides were divided into those dying by violent or non- violent means. The two main conclusions from this study are: (i) neurotransmitter- (5-HT and ACPD) stimulated [3H]PI hydrolysis was unaltered in depression, and (ii) antidepressant treatment did not modify PI-mediated signal transduction.<p /> <p>Language: en</p>
LA  - en
SN  - 1461-1457
UR  - http://dx.doi.org/10.1017/S1461145700001851
ID  - ref1
ER  -