TY  - JOUR
PY  - 2002//
TI  - Distribution of naproxen, dibenzepin and promazine in various tissues after acute overdosage
JO  - Acta Poloniae Toxicologica
A1  - Baczek, T.
A1  - Kaliszan, M.
A1  - Szpiech, B.
SP  - 153
EP  - 158
VL  - 10
IS  - 2
N2  - Concentration of naproxen, dibenzepin and promazine in blood, gastric juice, brain, liver and kidney was determined in biological material taken post mortem after acute overdosage, from a female aged 31, by means of high performance liquid chromatography (HPLC). Distribution of the drugs was related to their lipophilicity parameter, log P (logarithm of n-octanol-water partition coefficient). Blood levels of the drugs seemed to correlate with their lipophilicity. However, the relations between drug concentration ratios in different tissues and log P are not straightforward and indicate that not only passive diffusion but also some specific membrane transport mechanisms are involve in distribution. High concentrations of dibenzepin and promazine in the brain were the most probable cause of death of the suicide.<p /> <p>Language: en</p>
LA  - en
SN  - 1230-6967
UR  - http://dx.doi.org/
ID  - ref1
ER  -