TY  - JOUR
PY  - 2024//
TI  - Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study
JO  - Journal of neural transmission
A1  - Luo, Guoshuai
A1  - Wang, Shuo
A1  - Gou, Lei
A1  - Li, Cui
A1  - Yao, Cong
A1  - Jing, Yifan
A1  - Xuekelaiti, Zaimina
A1  - Li, Jie
A1  - Zhang, Xiang-Yang
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - This study aims to investigate sex differences and risk factors for self-reported suicide attempts among Chinese Han middle-aged patients with first-episode drug-naïve (FEDN) anxious depression (AD). A total of 1796 patients with FEDN major depressive disorder were enrolled in this study, including 341 middle-aged patients with AD. We compared the prevalence, demographics, and clinical characteristics of suicide attempts between male and female patients with FEDN middle-aged AD. We also explored the risk factors for self-reported suicide attempts in this population using binary logistic regression analysis. The male/female ratio was 91/250 and the age of onset was 51.50 ± 4.13. Our results showed that there were no significant sex differences in the prevalence of self-reported suicide attempts in middle-aged patients with FEDN AD. However, we did find significant differences in several demographic and clinical characteristics between self-reported suicide attempters and non-suicide attempters. Moreover, severe anxiety, measured by the Hamilton Anxiety Rating Scale score, was identified as a risk factor for self-reported suicide attempts in female middle-aged AD patients. Additionally, elevated thyroid peroxidase antibody (TPOAb) levels were linked to self-reported suicide attempts in male AD patients. Our findings suggest that there are no significant sex differences in the prevalence of self-reported suicide attempts in this population, but there may be sex-specific risk factors for self-reported suicide attempts in middle-aged AD. Clinical psychiatrists need to pay attention to thyroid hormone levels in middle-aged anxious depression.<p />  <p>Language: en</p>
LA  - en
SN  - 0300-9564
UR  - http://dx.doi.org/10.1007/s00702-024-02779-x
ID  - ref1
ER  -