TY - JOUR
PY - 2024//
TI - Parvalbumin interneurons in human ventromedial prefrontal cortex: a comprehensive post-mortem study of myelination and perineuronal nets in neurotypical individuals and depressed suicides with and without a history of child abuse
JO - Cerebral cortex
A1 - Théberge, Stéphanie
A1 - Belliveau, Claudia
A1 - Xie, Dongyue
A1 - Khalaf, Roy
A1 - Perlman, Kelly
A1 - Rahimian, Reza
A1 - Davoli, Maria Antonietta
A1 - Turecki, Gustavo
A1 - Mechawar, Naguib
SP - bhae197
EP - bhae197
VL - 34
IS - 5
N2 - Cortical parvalbumin interneurons (PV+) are major regulators of excitatory/inhibitory information processing, and their maturation is associated with the opening of developmental critical periods (CP). Recent studies reveal that cortical PV+ axons are myelinated, and that myelination along with perineuronal net (PNN) maturation around PV+ cells is associated with the closures of CP. Although PV+ interneurons are susceptible to early-life stress, their relationship between their myelination and PNN coverage remains unexplored. This study compared the fine features of PV+ interneurons in well-characterized human post-mortem ventromedial prefrontal cortex samples (n = 31) from depressed suicides with or without a history of child abuse (CA) and matched controls. In healthy controls, 81% of all sampled PV+ interneurons displayed a myelinated axon, while a subset (66%) of these cells also displayed a PNN, proposing a relationship between both attributes. Intriguingly, a 3-fold increase in the proportion of unmyelinated PV+ interneurons with a PNN was observed in CA victims, along with greater PV-immunofluorescence intensity in myelinated PV+ cells with a PNN. This study, which is the first to provide normative data on myelination and PNNs around PV+ interneurons in human neocortex, sheds further light on the cellular and molecular consequences of early-life adversity on cortical PV+ interneurons. Language: en
LA - en
SN - 1047-3211
UR - http://dx.doi.org/10.1093/cercor/bhae197
ID - ref1
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