TY  - JOUR
PY  - 2000//
TI  - Hepatitis C virus co-infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus-positive patients
JO  - Journal of viral hepatitis
A1  - Piroth, L.
A1  - Grappin, M.
A1  - Cuzin, L.
A1  - Mouton, Y.
A1  - Bouchard, O.
A1  - Raffi, F.
A1  - Rey, D.
A1  - Peyramond, D.
A1  - Gourdon, F.
A1  - Drobacheff, C.
A1  - Lombart, M. L.
A1  - Lucht, F.
A1  - Besnier, J. M.
A1  - Bernard, L.
A1  - Chavanet, P.
A1  - Portier, H.
SP  - 302
EP  - 308
VL  - 7
IS  - 4
N2  - A longitudinal study of human immunodeficiency virus (HIV)-infected individuals followed-up in 13 centres was performed to assess the influence of hepatitis C virus (HCV) on the clinical and immunological evolution of HIV-infected patients. Eight-hundred and twelve HIV-infected patients with known HIV acquisition date, 89 co-infected with HCV, were included in the cohort. Clinical progression was defined as: 30% decrease of Karnofsky's index; and/or 20% body weight loss; and/or acquired immune deficiency syndrome (AIDS)-defining illness; and/or death (except by accident, suicide, or overdose). Immunological progression was defined as a decrease of initial CD4 count to below 200 mm(-3). If immunological progression was not statistically different between groups (P=0.25), clinical progression was significantly faster in HCV-HIV co-infected patients in univariate (P=0.02) and multivariable survival analysis (hazard ratio=1.63, P=0.03). This argues for active management of hepatitis C chronic infection among HCV-HIV co-infected patients.<p /> <p>Language: en</p>
LA  - en
SN  - 1352-0504
UR  - http://dx.doi.org/10.1046/j.1365-2893.2000.00227.x
ID  - ref1
ER  -