TY  - JOUR
PY  - 2004//
TI  - Mirtazapine-associated rapid weight gain and decreased physical activity
JO  - Journal of pharmacy practice and research
A1  - Kethini, T.
A1  - Alderman, C.P.
A1  - Doecke, C.J.
SP  - 308
EP  - 309
VL  - 34
IS  - 4
N2  - BACKGROUND: Mirtazapine-associated weight gain is widely documented. However, data demonstrating changes in physical activity associated with mirtazapine have not been published. <br><br>AIM: To describe a case of rapid weight gain and decreased physical activity associated with mirtazapine. Clinical features: A 55-year-old Caucasian man was admitted after attempting suicide and was diagnosed with post-traumatic stress disorder and depression. He was treated with mirtazapine 30 mg daily and zopiclone 15 mg at night during 5 weeks of hospitalisation and discharged on the same therapy. As a part of a research protocol, the patient was followed closely for 17 weeks after first observation, and his body weight, physical activity and biochemical parameters were recorded. Outcomes: The patient's weight increased by 10 kg within 2 weeks of starting mirtazapine, and at the end of the 17-week follow-up period the total weight gain was 17.5 kg. The fasting blood glucose and serum lipid concentrations had also increased. At the conclusion of the follow-up period, physical activity levels had decreased by 40% relative to baseline. An objective causality assessment revealed that the relationship between mirtazapine and weight gain could be regarded as possible. <br><br>CONCLUSION: Patients on mirtazapine should be monitored for changes in weight and offered information about diet and exercise to assist in weight management.<p /> <p>Language: en</p>
LA  - en
SN  - 1445-937X
UR  - http://dx.doi.org/10.1002/jppr2004344308
ID  - ref1
ER  -