TY  - JOUR
PY  - 2004//
TI  - Type 2 diabetes mellitus with lactic acidosis and acute renal failure induced by metformin overdose in suicide
JO  - Journal of the Japan Diabetes Society
A1  - Iwai, H.
A1  - Ohno, Y.
A1  - Itoh, H.
A1  - Endo, T.
A1  - Komaki, K.
A1  - Ishii, S.
A1  - Morioka, Y.
A1  - Imonawa, H.
A1  - Kiyokawa, T.
A1  - Harada, T.
A1  - Hirota, N.
A1  - Yamauchi, T.
A1  - Miyatake, T.
A1  - Aoki, N.
SP  - 439
EP  - 445
VL  - 47
IS  - 6
N2  - A 38-year-old man treated with oral metformin and insulin injection for type 2 diabetes mellitus since 5 years ago attempted on April 5, 2003, to kill himself by overdosing on metformin (26.25 g) and was seen for nausea, vomiting, epigastralgia, and disturbance of consciousness. He was diagnosed with lactic acidosis and acute renal failure based on findings of elevated serum lactic acid (178.9 mg/dl), urea nitrogen (BUN) (128 mg/dl), and creatinine (11.8 mg/dl), and metabolic acidosis with a wide anion gap(anion gap 58.8, pH 7.219). Lactic acidosis and acute renal failure were improved by continuous hemodialysis filtration (CHDF) and intravenous fluid therapy. Diabetic control was improved by insulin therapy. After that, the patient was discharged. CHDF is recommended to treat metformin-induced lactic acidosis to maintain blood circulation.<p /> <p>Language: ja</p>
LA  - ja
SN  - 0021-437X
UR  - http://dx.doi.org/
ID  - ref1
ER  -