TY  - JOUR
PY  - 2005//
TI  - Hemoperfusion of amitriptyline and nortriptylin - An in vitro study
JO  - Aktuality v Nefrologii
A1  - Derzsiová, K.
A1  - Mydlík, M.
A1  - Petríková, V.
A1  - Molčányiová, A.
SP  - 6
EP  - 10
VL  - 11
IS  - 1
N2  - The absorption efficacy of charcoal, Amberlite XAD-2 and Amberlite XAD-4, in hemoperfusion using amitriptyline and nortriptyline in vitro was assessed. Overall, 15 amitriptyline and nortriptyline hemoperfusion procedures were carried out in vitro using a closed system and the above sorbents. An NaCl solution (with a volume of 3,000 ml of 0.9% of NACl) served as the perfusate. Amitriptyline and nortriptyline levels in the perfusate were 13.1±0.5 mg/l and 12.1±0.6mg/l, respectively. Individual hemoperfusion procedures lasted 5 hours. During charcoal-based hemoperfusion, amitriptyline and nortriptyline levels in perfusate at 300 minutes were 2.09±0.21 mg/l and 1.95±0.14 mg/l, respectively. Hemoperfusion using Amberlite XAD-2 and XAD-4 decreased amitriptyline and nortriptyline levels to zero as early as 180 minutes. Amitriptyline and nortriptyline extraction and clearance rates reached their peak values (extraction: 1.0; clearance: 200 ml/min) at 120 minutes during hemoperfusion with Amberlite XAD-2 and XAD-4. Based on the results of our in vitro study, we recommend to use tricyclic antidepressants for managing acute poisoning with amitriptyline and nortriptyline in man, and hemoperfusion with Amberlite XAD-4 or XAD-2 within 6 hours of acute poisoning. In addition, we performed two hemoperfusion procedures with Amberlite XAD-4 in a 44-year-old woman ingesting amitriptyline in a suicide attempt. The patient recovered successfully.<p /> <p>Language: cs</p>
LA  - cs
SN  - 1210-955X
UR  - http://dx.doi.org/
ID  - ref1
ER  -