TY  - JOUR
PY  - 2007//
TI  - Colchicine related pancytopenia unresponsive to granulocyte colony stimulating factor
JO  - Case Reports and Clinical Practice Review
A1  - Sedat, K.
A1  - Alper, K.
A1  - Haktan, K.
A1  - Selim, T.
SP  - 13
EP  - 15
VL  - 8
IS  - 
N2  - BACKGROUND: Colchicine overdose is uncommon but extremely serious and it is associated with considerable mortality. Previous reports have shown that granulocyte colony-stimulating factor therapy was an effective method of treating the colchicine related pancytopenia. Case Reports: We describe a case of suicidal ingestion of 15 mg of colchicine in a previously healthy 23-yearsold woman. During nasogastric tube insertion, nasal bleeding developed in the emergency room and stopped after anterior nasal tamponage. Following days, patient's platelet counts decreased to 14.9 K/UL due to bone marrow suppression. In spite of all therapeutic approach including granulocyte colony-stimulating factor, our patient died on 5th day due to severe bleeding. <br><br>CONCLUSIONS: Bone marrow suppression may be resistant to granulocyte colony-stimulating factor in colchicine poisoning. We recommend that all invasive procedures were performed more carefully in patient doubted colchicine ingestion.<p /> <p>Language: en</p>
LA  - en
SN  - 1643-3742
UR  - http://dx.doi.org/
ID  - ref1
ER  -