TY  - JOUR
PY  - 2007//
TI  - Sub-acute toxicosis caused by a multiple doses tegafur/uracil (UFT) for suicide: A case report
JO  - Kitakanto medical journal
A1  - Hagiwara, S.
A1  - Ogino, T.
A1  - Takahashi, Y.
A1  - Isaka, A.
A1  - Nameki, T.
A1  - Kagoshima, K.
A1  - Yamada, T.
A1  - Ishihara, K.
A1  - Hiraishi, H.
A1  - Kurabayashi, K.
A1  - Handa, H.
A1  - Iino, Y.
SP  - 317
EP  - 320
VL  - 57
IS  - 4
N2  - Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1:4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur: 40000 mg/uracil 9960mg) in an effort to commit suicide, and suffered from sub-acute toxicosis (main symptoms were bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G -CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought.<p /> <p>Language: en</p>
LA  - en
SN  - 1343-2826
UR  - http://dx.doi.org/10.2974/kmj.57.317
ID  - ref1
ER  -