TY  - JOUR
PY  - 2008//
TI  - Long-term event-related potential changes following organophosphorus insecticide poisoning
JO  - Clinical neurophysiology
A1  - Dassanayake, Waidyaratne Dassanayake Mudiyanselage Tharaka Lagath
A1  - Weerasinghe, V.
A1  - Dangahadeniya, U.
A1  - Kularatne, Keerthi
A1  - Dawson, Andrew
A1  - Karalliedde, L.
A1  - Senanayake, N.
SP  - 144
EP  - 150
VL  - 119
IS  - 1
N2  - OBJECTIVE: To determine prolonged effects of organophosphorus (OP) insecticide poisoning on cognitive event-related potentials (ERPs). METHODS: ERPs of a group of 32 patients recovered from cholinergic phase of OP insecticide poisoning were compared with those of two matched control groups: 32 healthy volunteers and nine patients hospitalised with paracetamol overdose. A follow-up assessment was done in 21 patients (66% of the initial sample) 6 months after OP intoxication and the findings were compared with their initial ERP data. RESULTS: Patients showed highly significant prolongation of P300 latency, compared to healthy controls (p=0.003) and the controls with paracetamol overdose (p=0.016). Follow-up ERP findings of the patients revealed that this impairment remained unchanged even 6 months after OP poisoning (p=0.790). There was no significant difference in N100, P200 and N200 latencies or P300 amplitude either among the groups or between the two assessments of the patients with OP poisoning. CONCLUSIONS: Our results suggest that acute OP poisoning causes a delay in cognitive processes involved in stimulus classification, lasting at least for 6 months. SIGNIFICANCE: These findings highlight the possibility of development of long-lasting cognitive deficits following OP insecticide poisoning, and warrant longer-term prospective studies to determine whether this impairment is permanent.<p />  <p>Language: en</p>
LA  - en
SN  - 1388-2457
UR  - http://dx.doi.org/10.1016/j.clinph.2007.09.134
ID  - ref1
ER  -