TY  - JOUR
PY  - 2024//
TI  - Childhood adversity and time-to-pregnancy in a preconception cohort
JO  - American journal of epidemiology
A1  - Lovett, Sharonda M.
A1  - Orta, Olivia R.
A1  - Boynton-Jarrett, Renee
A1  - Wesselink, Amelia K.
A1  - Ncube, Collette N.
A1  - Nillni, Yael I.
A1  - Hatch, Elizabeth E.
A1  - Wise, Lauren A.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - We examined the association between childhood adversity and fecundability (the per-cycle probability of conception), and the extent to which childhood social support modified this association. We used data from 6,318 female participants aged 21-45 years in Pregnancy Study Online (PRESTO), a North American prospective preconception cohort study (2013-2022). Participants completed a baseline questionnaire, bimonthly follow-up questionnaires (until pregnancy or a censoring event), and a supplemental questionnaire on experiences across the life course including adverse childhood experiences (ACE) and social support (using the modified Berkman-Syme Social Network Index [SNI]). We used proportional probabilities regression models to compute fecundability ratios (FR) and 95% confidence intervals (CI), adjusting for potential confounders and precision variables. Adjusted FRs for ACE scores 1-3 and ≥4 vs. 0 were 0.91 (95% CI: 0.85, 0.97) and 0.84 (95% CI: 0.77, 0.91), respectively. FRs for ACE scores ≥4 vs. 0 were 0.86 (95% CI: 0.78, 0.94) among participants reporting high childhood social support (SNI ≥4) and 0.78 (95% CI: 0.56, 1.07) among participants reporting low childhood social support (SNI <4). Our findings confirm results from two previous studies and indicate that high childhood social support slightly buffered the effects of childhood adversity on fecundability.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-9262
UR  - http://dx.doi.org/10.1093/aje/kwae085
ID  - ref1
ER  -