TY  - JOUR
PY  - 2010//
TI  - Protracted deep coma after bromazepam poisoning
JO  - International journal of clinical pharmacology and therapeutics
A1  - Lakhal, K.
A1  - Pallancher, S.
A1  - Mathieu-Daude, J.-c.
A1  - Harry, P.
A1  - Capdevila, X.
SP  - 79
EP  - 83
VL  - 48
IS  - 1
N2  - BACKGROUND: Bromazepam intoxication is very common but surprisingly rarely reported. Case description: We describe the case of a 73-year-old woman who suffered from a prolonged coma after acute self poisoning with bromazepam (serum concentration of 2,000 ng/ml at admission, 2 - 10 hours after ingestion of up to 180 mg) and zolpidem (900 ng/ml at admission). Only the former lasted at toxic concentrations. Recovery of consciousness allowed extubation on Day 16. Repeat-dose activated charcoal (25 g every 6 h from Day 14 to 16) resulted in minimal effects on bromazepam grossly estimated kinetics. <br><br>CONCLUSION: Despite its relativel low theoretic half-life, bromazepam may induce a prolonged life-threatening coma, even in the absence of renal or hepatic failure. © 2010 Dustri-Verlag Dr. K. Feistle.<p /> <p>Language: en</p>
LA  - en
SN  - 0946-1965
UR  - http://dx.doi.org/10.5414/CPP48079
ID  - ref1
ER  -