TY  - JOUR
PY  - 2011//
TI  - Mitochondrial respiratory chain activity in an animal model of mania induced by ouabain
JO  - Acta neuropsychiatrica
A1  - Freitas, T.P.
A1  - Rezin, G.T.
A1  - Fraga, D.B.
A1  - Moretti, M.
A1  - Vieira, J.S.
A1  - Gomes, L.M.
A1  - Borges, L.S.
A1  - Valvassori, S.S.
A1  - Quevedo, J.
A1  - Streck, E.L.
SP  - 106
EP  - 111
VL  - 23
IS  - 3
N2  - OBJECTIVES: Bipolar disorder (BD) is a mental illness associated with higher rates of suicide. The present study aims to investigate the brain mitochondrial respiratory chain activity in an animal model of mania induced by ouabain. <br><br>METHODS: Adult male Wistar rats received a single intracerebroventricular administration of ouabain (10-3 and 10 -2 M) or vehicle. Locomotor activity was measured using the open field test. Mitochondrial respiratory chain activity was measured in the brain of rats 1 h and 7 days after ouabain administration. <br><br>RESULTS: Our results showed that spontaneous locomotion was increased 1 h and 7 days after ouabain administration. Complexes I, III and IV activities were increased in the prefrontal cortex, hippocampus and striatum immediately after the administration of ouabain, at the concentration of 10-3 and 10-2 M. Moreover, complex II activity was increased only in the prefrontal cortex at the concentration of 10-2 M. On the other hand, no significant alterations were observed in complex I activity 7 days after ouabain administration. However, an increase in complexes II, III and IV activities was observed only in the prefrontal cortex at the concentration of 10-2 M. <br><br>CONCLUSION: Our findings suggest an increase in the activities of mitochondrial respiratory chain in this model of mania. A possible explanation is that these findings occur as a rebound effect trying to compensate for a decrease of ATP deprivation in BD. The present findings suggest that this model may present good face validity and a limitation in construct validity. © 2011 John Wiley & Sons A/S.<p /> <p>Language: en</p>
LA  - en
SN  - 0924-2708
UR  - http://dx.doi.org/10.1111/j.1601-5215.2011.00543.x
ID  - ref1
ER  -