TY  - JOUR
PY  - 2015//
TI  - Neuropsychiatric disorders in cushing's syndrome
JO  - Frontiers in neuroscience
A1  - Pivonello, R.
A1  - Simeoli, C.
A1  - De Martino, M.C.
A1  - Cozzolino, A.
A1  - De Leo, M.
A1  - Iacuaniello, D.
A1  - Pivonello, C.
A1  - Negri, M.
A1  - Pellecchia, M.
A1  - Iasevoli, F.
A1  - Colao, A.
SP  - 
EP  - 
VL  - 9
IS  - MAR
N2  - Endogenous Cushing's syndrome (CS), a rare endocrine disorder characterized by cortisol hypersecretion, is associated with psychiatric and neurocognitive disorders. Major depression, mania, anxiety and neurocognitive impairment are the most important clinical abnormalities. Moreover, patients most often complain of impairment in quality of life, interference with family life, social and work performance. Surprisingly, after hypercortisolism resolution, despite the improvement of the overall prevalence of psychiatric and neurocognitive disorders, the brain volume loss at least partially persists and it should be noted that some patients may still display depression, anxiety, panic disorders and neurocognitive impairment. This brief review aimed at describing the prevalence of psychiatric and neurocognitive disorders and their characterization both during the active and remission phases of CS. The last section of this review is dedicated to quality of life, impaired during active CS and only partially resolved after resolution of hypercortisolism. © 2015 Pivonello, Simeoli, De_martino, Cozzolino, De_leo, Iacuaniello, Pivonello, Negri, Pellecchia, Iasevoli and Colao.<p /> <p>Language: en</p>
LA  - en
SN  - 1662-4548
UR  - http://dx.doi.org/10.3389/fnins.2015.00129
ID  - ref1
ER  -