TY  - JOUR
PY  - 2015//
TI  - Status epilepticus following self-poisoning of lacosamide and lamotrigine: A case report with follow-up of drug serum concentrations
JO  - Toxicologie analytique et clinique
A1  - Deslandes, G.
A1  - Bouquie, R.
A1  - Lorber, J.
A1  - Bruneau, C.
A1  - Grégoire, M.
A1  - Grison-Hernando, H.
A1  - Pineau, A.
A1  - Monteil-Ganière, C.
A1  - Azoulay, C.
A1  - Dailly, E.
A1  - Villers, D.
A1  - Harry, P.
A1  - Jolliet, P.
SP  - 88
EP  - 90
VL  - 27
IS  - 2
N2  - A 26-year-old male with a history of atypical left temporal lobe epilepsy was found at home by emergency unit. He ingested 6g of lacosamide and 8g of lamotrigine. At emergency unit arrival, the patient was lying in his bathroom. He was agitated and experienced tonic-clonic seizure. Administration of diazepam allowed control of status epilepticus. Then, stable vital sign allowed a quick transfer to emergency department. At arrival, he presented a deep coma (Glasgow Coma Score 3), his pupils were symmetrical and reactive. Tracheal intubation was performed; he was then transferred to intensive care unit. Continuous infusion of propofol and clonazepam were administered allowing clinical and electroencephalographic control of the epileptiform discharge. The infusion was totally stopped after 69hours allowing rapid awakening and extubation. Monitoring of lacosamide and lamotrigine serum concentrations were carried out over 70hours. Plasma peak concentrations were reached 10hours after intake. Peak plasma concentrations were 52.4mg/L for lamotrigine and 53.9mg/L for lacosamide. Calculated elimination half-lifes were approximately 34hours and 15-20hours for lamotrigine and lacosamide. These results were comparable with those measured in healthy subjects. © 2015 Société Française de Toxicologie Analytique.<p /> <p>Language: en</p>
LA  - en
SN  - 2352-0078
UR  - http://dx.doi.org/10.1016/j.toxac.2015.02.002
ID  - ref1
ER  -