TY  - JOUR
PY  - 2016//
TI  - Relationships between mixed features and borderline personality disorder in 2811 patients with major depressive episode
JO  - Acta psychiatrica Scandinavica
A1  - Perugi, G.
A1  - Angst, J.
A1  - Azorin, J.-m.
A1  - Bowden, C.L.
A1  - Caciagli, A.
A1  - Mosolov, S.
A1  - Vieta, E.
A1  - Young, A.H.
SP  - 133
EP  - 143
VL  - 133
IS  - 2
N2  - OBJECTIVE: The study focused on the relationship between mixed depression and borderline personality disorder (BPD). <br><br>METHOD: The sample comprised 2811 patients with a major depressive episode (MDE). Clinical characteristics were compared in patients with (BPD+) and without (BPD-) comorbid BPD and in BPD+ with (MXS+) and without (MXS-) mixed features according to DSM-5 criteria. <br><br>RESULTS: A total of 187 patients (6.7%) met the criteria for BPD. A DSM-IV-TR diagnosis of bipolar disorder (BD) was significantly more frequent in patients with BPD+ than in patients with BPD. Patients with BPD+ were significantly younger and reported lower age at onset than BPD- Patients with BPD+ also showed more hypomania/mania in first-degree relatives in comparison with patients with BPD-, as well as more psychiatric comorbidity, mixed features, atypical features, suicide attempts, prior mood episodes and antidepressant-induced hypo/manic switches. Mixed features according to DSM-5 criteria were observed in 52 (27.8%) BPD+. In comparison with MXS-, MXS+ were significantly younger at age of onset and at prior mood episode and had experienced more mood episodes and hypo/manic switches with antidepressant treatments. <br><br>CONCLUSION: Major depressive episode patients with comorbid BPD reported a high prevalence of mixed features and BD. The presence of DSM-5 mixed features in MDE patients with BPD may be associated with complex course and reduced treatment response. © 2016 John Wiley & Sons A/S.<p /> <p>Language: en</p>
LA  - en
SN  - 0001-690X
UR  - http://dx.doi.org/10.1111/acps.12457
ID  - ref1
ER  -