TY  - JOUR
PY  - 2017//
TI  - Acidosis láctica por metformina: reporte de caso
JO  - Rev. colomb. anestesiol
A1  - Sanchez-Díaz, Jesus Salvador
A1  - Monares-Zepeda, Enrique
A1  - Martinez-Rodríguez, Enrique Antonio
A1  - Cortes-Román, Jorge Samuel
A1  - Torres-Aguilar, Oscar
A1  - Peniche-Moguel, Karla Gabriela
A1  - Diaz-Gutierrez, Susana Patricia
A1  - Pin-Gutierrez, Eusebio
A1  - Rivera-Solís, Gerardo
A1  - García-Méndez, Rosalba Carolina
A1  - Huanca-Pacaje, Juan Marcelo
A1  - Calyeca-Sánchez, Maria Veronica
SP  - 353
EP  - 359
VL  - 45
IS  - 4
N2  - Lactic acidosis is defined as the presence of pH &lt;7.35, blood lactate &gt;2.0 mmol/L and PaCO2 &lt;42 mmHg. However, the definition of severe lactic acidosis is controversial. The primary cause of severe lactic acidosis is shock. Although rare, metformin-related lactic acidosis is associated with a mortality as high as 50%. The treatment for metabolic acidosis, including lactic acidosis, may be specific or general, using sodium bicarbonate, trihydroxyaminomethane, carbicarb or continuous haemodiafiltration. The successful treatment of lactic acidosis depends on the control of the aetiological source. Intermittent or continuous renal replacement therapy is perfectly justified, shock being the argument for deciding which modality to use. We report a case of a male patient presenting with metformin poisoning as a result of attempted suicide, who developed lactic acidosis and multiple organ failure. The critical success factor was treatment with continuous haemodiafiltration.<p /> <p>Language: en</p>
LA  - en
SN  - 0120-3347
UR  - http://dx.doi.org/
ID  - ref1
ER  -