TY  - JOUR
PY  - 2021//
TI  - Midodrine overdose in children: A case report and review of treatment for hypertensive emergencies
JO  - Translational pediatrics
A1  - Jan, M.
A1  - Brothers, E.
A1  - Nakagawa, T.A.
SP  - 2398
EP  - 2401
VL  - 10
IS  - 9
N2  - Midodrine is an antihypotensive agent used primarily in the adult population for orthostatic hypotension and reflex syncope, postural orthostatic tachycardia syndrome (POTS), and hemodialysis-induced hypotension. Limited information about midodrine ingestion and overdose exists in children with only a single case series reported in the literature. Varying presentations of midodrine ingestion in children have not been shown to be acutely life-threatening in doses up to 50 mg. We present a case of a 12-year-old who intentionally ingested 100 mg of midodrine and presented with a hypertensive emergency and seizure activity. This is the largest reported dose ingested in a child. The patient was observed and treated with a nicardipine infusion in the pediatric intensive care unit (PICU). Prompt identification and treatment of symptoms contributed to a favorable outcome with no neurologic deficits and complete recovery from an intentional ingestion of midodrine. Mechanism, duration of action, and management of midodrine ingestion including treatment for a hypertensive emergency in children are discussed. Commonly used pharmacologic agents to treat hypertension are reviewed. This case report of a significant ingestion of midodrine reviews management of hypertensive emergencies and provides information and guidance to healthcare professionals unfamiliar with this medication and its potentially fatal effects. © 2021 AME Publishing Company. All rights reserved.<p /> <p>Language: en</p>
LA  - en
SN  - 2224-4336
UR  - http://dx.doi.org/10.21037/tp-21-153
ID  - ref1
ER  -