TY  - JOUR
PY  - 2017//
TI  - [Glioblastoma gene therapy and related delivery systems]
JO  - Medical Sciences Journal of Islamic Azad University
A1  - Muhammad Reza, Noori Daloii
A1  - Reza, Ahmadi beni
SP  - 149
EP  - 163
VL  - 27
IS  - 3
N2  - Gene therapy of glioblastoma multiforme is based on direct introduction of gene[s] to achieve anti-tumor effects and four types of it are examined: [A] suicide gene therapy; [B] immunomodulatory gene therapy; [C] tumor-suppressor gene therapy and [D] oncolytic gene therapy. Now, viral and nonviral vectors, tumor-tropic cell carriers with therapeutic gene[s] expression ability, and "intelligent" carriers, increase delivery, specificity, and toxicity against GBM. In this review, by using dozens of valid and updated academic papers and personal experiences of gene therapy methods and delivery systems relevant in glioblastoma, and its prospects are discussed. Also interesting prospective clinical trials of gene therapy for glioblastoma are mentioned<p /> <p>Language: fa</p>
LA  - fa
SN  - 1023-5922
UR  - http://dx.doi.org/
ID  - ref1
ER  -