TY  - JOUR
PY  - 2011//
TI  - Advancement and prospects of tumor gene therapy
JO  - Chinese Journal of Cancer
A1  - Zhang, Chao
A1  - Wang, Qing-Tao
A1  - Liu, He
A1  - Zhang, Zhen-Zhu
A1  - Huang, Wen-Lin
SP  - 182
EP  - 188
VL  - 
IS  - 12
N2  - Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based (tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes) and RNA-based (antisense oligonucleotides and RNA interference) approaches. In addition, immune response-based strategies (dendritic cell- and T cell-based therapy) are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.<p /> <p>Language: en</p>
LA  - en
SN  - 1000-467X
UR  - http://dx.doi.org/
ID  - ref1
ER  -