TY  - JOUR
PY  - 2010//
TI  - Effect of adenovirus-mediated CD/TK double suicide gene system on colorectal cancer growth and cytokines in the tumor microenvironment in mice
JO  - Nan Fang Yi Ke Da Xue Xue Bao
A1  - Yao, Xiao-jun
A1  - Huang, Zong-hai
A1  - Li, Qiang
A1  - Wang, Zhao-yang
SP  - 260
EP  - 262
VL  - 
IS  - 12
N2  - &lt;p&gt;&lt;b&gt;OBJECTIVE&lt;/b&gt;To evaluate the effect of adenovirus-mediated CD/TK double suicide gene system on tumor growth and cytokine levels in the tumor microenvironment in mice bearing transplanted colorectal cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS&lt;/b&gt;CT26 cells were implanted subcutaneously into 30 Balb/c mice, which were subsequently randomized into the control (n=15) and experimental group (n=15). After the tumor formation, CD/TK double suicide gene system was administered for tumor treatment, and the changes in the tumor volume, tumor inhibition rate, and levels of cytokines in the tumor microenvironment were investigated.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS&lt;/b&gt;CD/TK double suicide gene system resulted in a significant inhibition of the tumor growth and significantly increased levels of such cytokines as IL-2, IL-10, TNFalpha and IFNgamma in the tumor microenvironment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION&lt;/b&gt;CD/TK double suicide gene system produces significant tumor inhibition effect and causes obvious cytokine changes in the tumor microenvironment in mice bearing transplanted colorectal cancer.&lt;/p&gt;<p /> <p>Language: zh</p>
LA  - zh
SN  - 1673-4254
UR  - http://dx.doi.org/
ID  - ref1
ER  -