TY  - JOUR
PY  - 2004//
TI  - Monocyte Chemoattractant Protein-1(MCP1) -2518 Polymorphism and Bipolar I Disorder
JO  - Journal of Korean Neuropsychiatric Association
A1  - Pae, Chi-Un
A1  - Kim, Tae-Suk
A1  - Jang, Woo-Young
A1  - Kim, Jung-Jin
A1  - Lee, Chang-Uk
A1  - Lee, Soo-Jung
A1  - Jun, Tae-Youn
A1  - Lee, Chul
A1  - Paik, In-Ho
SP  - 524
EP  - 528
VL  - 
IS  - 
N2  - OBJECTIVES: Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD. <br><br>METHODS: Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. <br><br>RESULTS: Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. <br><br>CONCLUSION: Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.<p /> <p>Language: ko</p>
LA  - ko
SN  - 1015-4817
UR  - http://dx.doi.org/
ID  - ref1
ER  -