TY  - JOUR
PY  - 2018//
TI  - Fibrosis pulmonar aguda asociada a intoxicación por Paraquat: caso clínico
JO  - Revista Medica de Chile
A1  - Cartagena, Sebastián
A1  - Díaz, Israel
A1  - Gutiérrez, Constanza
A1  - Dreyse, Jorge
A1  - Florenzano, Matías
A1  - Palavecino, Marcela
A1  - Regueira, Tomás
SP  - 938
EP  - 941
VL  - 146
IS  - 7
N2  - Paraquat, a non-selective bipyridyl pesticide, is one of the leading causes of death from intoxication in many parts of Asia and America. It is the second most sold herbicide worldwide, being widely used in Chile. Its ingestion generates toxicity due to the release of superoxide radicals, mainly affecting kidneys, lungs and liver. There is no antidote available. We report a 31 years old male who ingested Paraquat for suicidal purposes. He developed an acute renal and hepatic failure and a rapidly progressive severe respiratory failure with images compatible with acute pulmonary fibrosis. No response to immunosuppressive treatment was observed. He died eight days after admission. The use of cyclophosphamide associated with glucocorticoids could lower risk of death the in these patients, although the pathophysiology of respiratory failure is still under study.<p /> <p>Language: es</p>
LA  - es
SN  - 0034-9887
UR  - http://dx.doi.org/10.4067/s0034-98872018000700938
ID  - ref1
ER  -