TY - JOUR PY - 2022// TI - Tantali fibromyalgic supplicium: Is there any relief with the antidepressant employment? A systematic review JO - Pharmacological research A1 - Ilari, Sara A1 - Passacatini, Lucia Carmela A1 - Malafoglia, Valentina A1 - Oppedisano, Francesca A1 - Maiuolo, Jessica A1 - Gliozzi, Micaela A1 - Palma, Ernesto A1 - Tomino, Carlo A1 - Fini, Massimo A1 - Raffaeli, William A1 - Mollace, Vincenzo A1 - Muscoli, Carolina SP - 106547 EP - 106547 VL - 186 IS - N2 - Widespread musculoskeletal pain characterizes fibromyalgia (FM), accompanied by sleep, fatigue, and mood problems. Chronic stress and depression play a crucial role in the etiology and pathophysiology of FM. They may contribute to a dysregulation of the central pain mechanisms together with the neuroendocrine and immune systems. Pharmacological treatments are the first-line therapy to reduce the symptoms of FM. The US Food and Drug Administration (FDA) indicated gabapentinoid, pregabalin, duloxetine, and milnacipran for adult patients. An alternative approach is widely used, based on therapies including interventions in patient education, behavioral therapy, exercise, pain management, and a healthy diet. A systematic search was performed on PubMed, MEDLINE, EMBASE, and Web of Science databases. The authors established the selection, inclusion, and exclusion criteria. We found a total of 908 articles. This systematic review will include ten articles selected after excluding duplicates and reading the abstracts and full texts. All studies related the effect of drugs to various symptoms caused by fibromyalgia patients with depression, such as insomnia/sleepiness, depression, suicide, difficulty walking/working, pain, fatigue, and nervousness. Although, we concluded that antidepressant drugs are effective in treating depression and pain in fibromyalgia, further studies are needed to understand the etiology of this disease and to find a combination of therapies to increase tolerability and adherence of the patient to the drug, decreasing the adverse effects.

Language: en

LA - en SN - 1043-6618 UR - http://dx.doi.org/10.1016/j.phrs.2022.106547 ID - ref1 ER -