TY  - JOUR
PY  - 2022//
TI  - Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study
JO  - Environment international
A1  - Andersen, Zorana J.
A1  - Zhang, Jiawei
A1  - Jørgensen, Jeanette T.
A1  - Samoli, Evangelia
A1  - Liu, Shuo
A1  - Chen, Jie
A1  - Strak, Maciej
A1  - Wolf, Kathrin
A1  - Weinmayr, Gudrun
A1  - Rodopolou, Sophia
A1  - Remfry, Elizabeth
A1  - de Hoogh, Kees
A1  - Bellander, Tom
A1  - Brandt, Jørgen
A1  - Concin, Hans
A1  - Zitt, Emanuel
A1  - Fecht, Daniela
A1  - Forastiere, Francesco
A1  - Gulliver, John
A1  - Hoffmann, Barbara
A1  - Hvidtfeldt, Ulla A.
A1  - Monique Verschuren, W. M.
A1  - Jöckel, Karl-Heinz
A1  - So, Rina
A1  - Cole-Hunter, Tom
A1  - Mehta, Amar J.
A1  - Mortensen, Laust H.
A1  - Ketzel, Matthias
A1  - Lager, Anton
A1  - Leander, Karin
A1  - Ljungman, Petter
A1  - Severi, Gianluca
A1  - Boutron-Ruault, Marie-Christine
A1  - Magnusson, Patrik K. E.
A1  - Nagel, Gabriele
A1  - Pershagen, Göran
A1  - Peters, Annette
A1  - Rizzuto, Debora
A1  - van der Schouw, Yvonne T.
A1  - Schramm, Sara
A1  - Stafoggia, Massimo
A1  - Katsouyanni, Klea
A1  - Brunekreef, Bert
A1  - Hoek, Gerard
A1  - Lim, Youn-Hee
SP  - 107581
EP  - 107581
VL  - 170
IS  - 
N2  - Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM(2.5)), nitrogen dioxide (NO(2)), black carbon (BC), ozone (O(3)), and 8 PM(2.5) components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO(2) (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m(3)), PM(2.5) (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m(3)), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10(-5)/m) with psychiatric disorders mortality, as well as with suicide (NO(2): HR = 1.13 [95 % CI: 0.92, 1.38]; PM(2.5): HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O(3) and 8 PM(2.5) components with any of the three mortality outcomes. Long-term exposure to NO(2), PM(2.5), and BC may lead to premature mortality from psychiatric disorders and suicide.<p /> <p>Language: en</p>
LA  - en
SN  - 0160-4120
UR  - http://dx.doi.org/10.1016/j.envint.2022.107581
ID  - ref1
ER  -