TY  - JOUR
PY  - 2022//
TI  - RETRACTED: Short- and Long-Term Influences of Benzodiazepine and Z-Drug Use in Patients with Bipolar Disorder Combined Sleep Disturbance during Affective Period: A Nine-Month Follow-Up Analysis
JO  - Disease markers
A1  - Huang, Haijing
A1  - Cui, Lvchun
A1  - Wang, Fan
A1  - Chen, Yiming
A1  - Hong, Wu
A1  - Fang, Yiru
A1  - Cao, Lan
A1  - Liu, Xiaohua
A1  - Wang, Meiti
A1  - Lyu, Dongbin
A1  - Zhang, Mengke
A1  - Qian, Nuoshi
A1  - Kong, Shuqi
SP  - 6799898
EP  - 6799898
VL  - 2022
IS  - 
N2  - BACKGROUND: Sleep disturbances and benzodiazepine (BZD)/Z-drug use are common in patients with bipolar disorder (BD). <br><br>OBJECTIVE: To investigate the short- and long-term effects of BZD/Z-drug use during acute affective episode. <br><br>METHODS: Participants diagnosed with BD as well as sleep disturbance chose BZDs/Z-drugs or not at will. Manic and depressive symptoms were assessed by Mental Disorders Questionnaire (MDQ) and Quick Inventory of Depressive Symptoms (QIDS) as self-reporting surveys. The participants were assessed by trained evaluators at baseline and months 1, 3, 6, and 9. <br><br>RESULTS: 61 patients with BD combined sleep disturbances were studied. At baseline, patients who used BZDs/Z-drugs had more amount of mood stabilizers (p = 0.038), other psychotropic medications (p = 0.040), and more risk of suicide attempt (p = 0.019). The BZD/Z-drug group had a significantly higher QIDS reductive ratio as compared with the no BZD/Z-drug group at month 1; no significant differences in the variability of MDQ, QIDS reductive ratio, or recurrence rate were found between these two groups at baseline, month 1, month 3, month 6, or month 9. <br><br>CONCLUSIONS: During acute affective episode, patients with BD combined sleep disturbance who took BZDs/Z-drugs tended to use more amount of mood stabilizers. Polytherapy of BZDs/Z-drugs or other psychiatric drugs could increase suicide attempt during an acute affective episode. BZD/Z-drug use, however, had a significant effect on helping depressive symptoms alleviate during affective period.<p /> <p>Language: en</p>
LA  - en
SN  - 0278-0240
UR  - http://dx.doi.org/10.1155/2022/6799898
ID  - ref1
ER  -