TY  - JOUR
PY  - 2022//
TI  - The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology
JO  - Frontiers in network physiology
A1  - Klerman, Elizabeth B.
A1  - Perlis, Michael L.
A1  - Grandner, Michael A.
A1  - Fernandez, Fabian-Xosé
A1  - Tubbs, Andrew S.
SP  - e830338
EP  - e830338
VL  - 1
IS  - 
N2  - Sufficient sleep with minimal interruption during the circadian/biological night supports daytime cognition and emotional regulation. Conversely, disrupted sleep involving significant nocturnal wakefulness leads to cognitive and behavioral dysregulation. Most studies to-date have examined how fragmented or insufficient sleep affects next-day functioning, but recent work highlights changes in cognition and behavior that occur when someone is awake during the night. This review summarizes the evidence for day-night alterations in maladaptive behaviors, including suicide, violent crime, and substance use, and examines how mood, reward processing, and executive function differ during nocturnal wakefulness. Based on this evidence, we propose the Mind after Midnight hypothesis in which attentional biases, negative affect, altered reward processing, and prefrontal disinhibition interact to promote behavioral dysregulation and psychiatric disorders.<p /> <p>Language: en</p>
LA  - en
SN  - 2674-0109
UR  - http://dx.doi.org/10.3389/fnetp.2021.830338
ID  - ref1
ER  -