TY  - JOUR
PY  - 2024//
TI  - "Weeding out" violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression
JO  - Aggression and violent behavior
A1  - Pederson, Casey A.
A1  - Braccagni, Giulia
A1  - Bortolato, Marco
A1  - Fite, Paula J.
A1  - Floris, Gabriele
SP  - e101948
EP  - e101948
VL  - 78
IS  - 
N2  - Recent shifts in societal attitudes towards cannabis have led to a dramatic increase in consumption rates in many Western countries, particularly among young people. This trend has shed light on a significant link between cannabis use disorder (CUD) and pathological reactive aggression, a condition involving disproportionate aggressive and violent reactions to minor provocations. The discourse on the connection between cannabis use and aggression is frequently enmeshed in political and legal discussions, leading to a polarized understanding of the causative relationship between cannabis use and aggression. However, integrative analyses from both human and animal research indicate a complex, bidirectional interplay between cannabis misuse and pathological aggression. On the one hand, emerging research reveals a shared genetic and environmental predisposition for both cannabis use and aggression, suggesting a common underlying biological mechanism. On the other hand, there is evidence that cannabis consumption can lead to violent behaviors while also being used as a self-medication strategy to mitigate the negative emotions associated with pathological reactive aggression. This suggests that the coexistence of pathological aggression and CUD may result from overlapping vulnerabilities, potentially creating a self-perpetuating cycle where each condition exacerbates the other, escalating into externalizing and violent behaviors. This article aims to synthesize existing research on the intricate connections between these issues and propose a theoretical model to explain the neurobiological mechanisms underpinning this complex relationship.<p />  <p>Language: en</p>
LA  - en
SN  - 1359-1789
UR  - http://dx.doi.org/10.1016/j.avb.2024.101948
ID  - ref1
ER  -